I know technically, (in a way) this already happened in a way when Baby lost his noodles in Dragon Ball GT and again when Piccolo was doing cocaine but ignoring those and dealing with a legit virus that is spreading across earth fast, how do you think the main characters would handle it? And before you say "They'd just collect the dragon balls and wish it to be cured!"... Shenron says no because it is a natural process and they have to deal with it.