Pilaf -
Pro - The Saga with the most focus on the Dragon Balls.
Con - The Boss Rabbit portion is entirely skippable.
21st -
Pro - I could really connect to Master Roshi in this Saga (and in the 22nd by extension).
Con - The stakes in this Saga weren't as high as they were in the 22nd and especially in the 23rd.
Red Ribbon -
Pro - There are many plot points in later Sagas that tie back to the Red Ribbon Saga.
Con - It dragged on for too long.
22nd -
Pro - Tenshinhan became Goku's first true rival.
Con - I was surprised at how much of a background character Chaozu was in the Manga during and after this Saga.
Piccolo Daimao -
Pro - Piccolo Daimao was the first major villain in the story.
Con - This is a minor complaint, but I always thought the transition from the 22nd to Piccolo Daimao was too fast.
23rd -
Pro - Goku becomes the savior of Earth here and finally wins a Budokai.
Con - Launch disappears from the Manga after this Saga.
Saiyan -
Pro - Goku VS Vegeta was the most engaging fight in the series, bar none.
Con - Introducing Battle Powers was a mistake, especially this late in the game.
Freeza -
Pro - Freeza was the best antagonist in the entire story.
Con - It was kind of frustrating seeing Yamcha and Tenshinhan do nothing in this Saga, even if they were both dead.
Androids -
Pro - Future Trunks was the best protagonist in the entire story.
Cons - The fights and antagonists (outside #16, #17, #18) were all underwhelming.
Cell -
Pro - Gohan killing Cell and succeeding Goku as the savior of Earth was epic. Trunks going back to the future to save his timeline was epic too.
Con - The Manga should have ended here.
Boo -
Pro - Two words. Hercule, Satan.
Con - All of the potential displayed in the 25th Budokai was flushed down the toilet immediately after that.
Pro - The Saga with the most focus on the Dragon Balls.
Con - The Boss Rabbit portion is entirely skippable.
21st -
Pro - I could really connect to Master Roshi in this Saga (and in the 22nd by extension).
Con - The stakes in this Saga weren't as high as they were in the 22nd and especially in the 23rd.
Red Ribbon -
Pro - There are many plot points in later Sagas that tie back to the Red Ribbon Saga.
Con - It dragged on for too long.
22nd -
Pro - Tenshinhan became Goku's first true rival.
Con - I was surprised at how much of a background character Chaozu was in the Manga during and after this Saga.
Piccolo Daimao -
Pro - Piccolo Daimao was the first major villain in the story.
Con - This is a minor complaint, but I always thought the transition from the 22nd to Piccolo Daimao was too fast.
23rd -
Pro - Goku becomes the savior of Earth here and finally wins a Budokai.
Con - Launch disappears from the Manga after this Saga.
Saiyan -
Pro - Goku VS Vegeta was the most engaging fight in the series, bar none.
Con - Introducing Battle Powers was a mistake, especially this late in the game.
Freeza -
Pro - Freeza was the best antagonist in the entire story.
Con - It was kind of frustrating seeing Yamcha and Tenshinhan do nothing in this Saga, even if they were both dead.
Androids -
Pro - Future Trunks was the best protagonist in the entire story.
Cons - The fights and antagonists (outside #16, #17, #18) were all underwhelming.
Cell -
Pro - Gohan killing Cell and succeeding Goku as the savior of Earth was epic. Trunks going back to the future to save his timeline was epic too.
Con - The Manga should have ended here.
Boo -
Pro - Two words. Hercule, Satan.
Con - All of the potential displayed in the 25th Budokai was flushed down the toilet immediately after that.